Following is a summary of published studies referencing ellura and validating its efficacy in promoting bacterial anti-adhesion and UTI prevention.
Note: urell is the European brand name for ellura.
FEATURED STUDY - November 2017
Does cranberry (ellura) have a role in catheter-associated urinary tract infections? Thomas D, et al. Weill Cornell Medical College. Cooper K, Columbia University Medical Centre. Can Urol Assoc J 2017;11(11):E421-4 Click here for PDF
- 22 patients with long-term indwelling catheters & recurrent symptomatic CA-UTIs were evaluated (defined by ≥ 103 (cfu)/mL of ≥ 1 bacterial species in a single catheter urine specimen and 2 UTIs in the previous 6 months).
- Once daily consumption of ellura containing 36 mg PAC for 6 months.
- NO UTIs were reported over the 6 months. No adverse events reported.
- 28% reduction of antibiotic resistances was also noted, with the greatest resistance among tetracycline, levofloxacin and cefazolin.
1. In-vitro and in-vivo evidence of dose-dependent decrease of uropathogenic E. coli virulence after consumption of commercial Vaccinium macrocarpon (cranberry) capsules. J. P. Lavigne, G. Bourg, et al.Clin Microbiol Infect 2008; 14:350-355. Click here for PDF
- A significant dose-dependent decrease in bacterial adherence in vitro was noted after consumption of 36 mg of ellura/urell cranberry (proanthocyanidins) capsules (p <0.001).
- The in-vivo model confirmed that E. coli strains had reduced ability to kill C. elegans after growth in the urine of patients who consumed ellura/urell.
- ellura capsules represent a new strategy in preventing urinary tract infections.
2. Dosage effect on uropathogenic E. coli anti- adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidins content: a multicenter randomized double blind study. Amy B. Howell, Henry Botto et al. BMC Infectious Diseases 2010, 10:94. Click here for PDF
- 36 mg of PAC (proanthocyanidins Type A) a day is necessary to inhibit bacterial adhesion to the epithelial cell lining of the urinary tract and is efficacious for UTI prevention.
- 36 mg demonstrated anti-adhesion activity between hours 1 to 6, with peak onset at 6 hours. (evident by low anti-adhesion scores following urine sample analysis of both doses)
- 72 mg of PAC (double-dose) may be taken for 2 days for maximum efficacy in protection against bacterial adhesion. This effect may offer nyctohemeral protection (AM/PM). Anti-adhesion benefits remained significant at 24 hours.
3. Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature. JP Lavigne, G. Bourg, et al. Universite de Montpellier, France. Elsevier Masson. July 2007. Click here for PDF
- ellura/urell significantly decreased the adhesion of E.coli with a dose-dependent effect regardless of antibiotic resistance to bacteria.
4. Effectiveness of a cranberry (Vaccinium macrocarpon) preparation in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty. Henry Botto & Yann Neuzillet. Scand J Urol Nephrol 2010, Vol. 44, No. 3, Pages 165-168. Click here for PDF
- Treatment with a cranberry compound (ellura/urell) high in proanthocyanidin is effective in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty (bladder reconstruction/augmentation).
5. Cranberries for preventing urinary tract infections (Review). Jepson et al. The Cochrane Library 2012, Issue 10.
- An updated review of studies: cranberry juice cannot currently be recommended for the prevention of UTIs.
- Other preparations need to be quantified using standardized methods to ensure the potency, and confirm they contain enough of the ‘active ingredient’ (36 mg PAC) for use in patients with recurrent UTIs. Note: ellura contains 36 mg PAC.
6. Cranberry (ellura/urell) syrup vs. trimethoprim in the prophylaxis of recurrent urinary tract infections among children: a controlled trial. Jose Uberos, et al. University Clinical Hospital Granada, Spain, Open Access Journal of Clinical Trials 2012:4, p.31-38. Note: syrup not yet available in the U.S. Click here for PDF
- Syrup derived from cranberry (with 36 mg PAC in every 5mL dose) was compared to trimethoprim
- Study confirms that proanthocyanidin syrup is safe for pediatrics and is equivalent to trimethoprim in respect to recurrent UTIs.
- Recurrent UTI patients, as well as those with vesicoureteral reflux went without an infection for more than 200 days when taking cranberry syrup (229 and 240 days, respectively).