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Uropathogenic bacteria (UPEC) like E.coli and others attach to the urinary tract causing infection. ellura’ s mechanism of action (MOA) is to bind the bacteria so that it cannot bind to you.

Soluble proanthocyanidins (PAC) found in the juice of the American cranberry, Vaccinium macrocarpon, inhibit the P-fimbriae of uropathogenic E. coli and other uropathogenic bacteria, so the bacteria do not adhere or attach to the urinary tract wall.1 This is known as Anti-Adhesion Activity (AAA). Attachment is the initial step of the infections. Soluble PAC inhibits P-fimbriae synthesis and induce bacterial deformation. This activity occurs in both antibiotic susceptible and resistant bacteria.2

ellura is a highly soluble juice only PAC extract offering the most potent AAA available. Based upon this, the minimum efficacious dose of ellura is 36 mg PACDMAC/A2 once per day3. This dosing strategy (36 mg) cannot be extrapolated to other cranberry supplements as they are composed of largely insoluble PAC.

“ellura exerts as much as 30% more AAA than the most potent insoluble whole berry product and 125% more AAA than the average cranberry supplement. AAA is not detectable in some cranberry supplements. There is a large amount of variability in the amount and AAA of PAC in commercially available cranberry products4,5.”

Amy Howell, Ph.D.; Research Scientist, Rutgers University


1. NEJM (1998) Volume 339:1085-1086 October 8, 1998 Number 15
2. Pathologie Biologie (2007) doi: 10.1016/j.patbio.2007.07.005
3. BMC Infectious Diseases, (2010) Howell et al.
4. American Herbal Pharmacopoeia (2016) Upton, R., and Brendler, T. ISBN: 1-929425-36-8 ISSN: 1538-0297.
5. American Journal of Obstetrics & Gynecology (2016) Chughtai, B.

 

MECHANISM OF ACTION
RESULTS IN ANTI-ADHESION 

 

*Amy B. Howell, Henry Botto et al. BMC Infectious Diseases 2010, 10:94.