2004: French company Pharmatoka petitions AFSSA (the French food safety agency) to confirm that PAC (proanthocyanidins) can inhibit bacteria from sticking to the urinary tract – known as the anti-adhesion effect.
AFSSA issues a health claim based on studies using supplements with 36 mg PAC.
2010: French DGCCRF (Directorate General for Competition, Consumer Affairs and Fraud Control) requires commercial products listing the claim to use the DMAC method [4-(dimethylamino)cinnamaldehyde] to measure PAC.
2011: The French food safety agency (now called ANSES) reviews additional studies and reaffirms that cranberry supplements with 36 mg PAC perform as claimed. Click here to learn more about the DMAC/A2 method now considered the gold standard in measuring PAC content.
After the 2004 confirmation, Pharmatoka launches urell®, the only cranberry product to contain 36 mg PAC measured by DMAC/A2. Urell gains in popularity and is rolled out worldwide, entering the U.S. market as ellura in late 2010. Today, a rapidly growing base of physicians and patients all over the globe trust ellura to maintain a clean urinary tract.